An overview of animal tissue decellularization techniques and clinical applications

Catalina Pineda-Molina; Sara María Galvis-Escobar; Juan David Molina-Sierra; Juan Pablo Ruíz-Soto; Maria Antonia Rego-Londoño

doi:10.33571/rpolitec.v20n39a3

Autores

Catalina Pineda-Molina Universidad CES https://orcid.org/0000-0001-7710-6119
Sara María Galvis-Escobar Biomedical Engineer. Biomedical Engineering Program, Engineering Faculty, Universidad CES https://orcid.org/0000-0001-5480-6884
Juan David Molina-Sierra Universidad CES https://orcid.org/0000-0002-6269-5448
Juan Pablo Ruíz-Soto Universidad CES https://orcid.org/0000-0002-8260-1744
Maria Antonia Rego-Londoño Universidad CES https://orcid.org/0000-0002-3366-8723

DOI:

https://doi.org/10.33571/rpolitec.v20n39a3

Palavras-chave:

Decellularization process, extracellular matrix, tissue, detergent, clinical applications

Resumo

Existe uma necessidade persistente e urgente de resolver problemas de escassez de doadores de tecidos e órgãos. Os tecidos descelularizados representam uma alternativa promissora a outros tratamentos biológicos e sintéticos que vêm sendo desenvolvidos, pois visam manter as características do tecido nativo que ajudariam nos processos regenerativos, como proliferação, adesão celular e presença de fatores de crescimento, minimizando as chances de uma resposta imune indesejada do hospedeiro. Na presente revisão, descrevemos as metodologias mais comuns para processos de descelularização, bem como as aplicações clínicas desses biomateriais.

Métricas do artigo

Resumo: 207 PDF (Español (España)): 126 HTML (Español (España)): 19

Métricas PlumX

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