An overview of animal tissue decellularization techniques and clinical applications

Catalina Pineda-Molina; Sara María Galvis-Escobar; Juan David Molina-Sierra; Juan Pablo Ruíz-Soto; Maria Antonia Rego-Londoño

doi:10.33571/rpolitec.v20n39a3

Autores/as

Catalina Pineda-Molina Universidad CES https://orcid.org/0000-0001-7710-6119
Sara María Galvis-Escobar Universidad CES https://orcid.org/0000-0001-5480-6884
Juan David Molina-Sierra Universidad CES https://orcid.org/0000-0002-6269-5448
Juan Pablo Ruíz-Soto Universidad CES https://orcid.org/0000-0002-8260-1744
Maria Antonia Rego-Londoño Universidad CES https://orcid.org/0000-0002-3366-8723

DOI:

https://doi.org/10.33571/rpolitec.v20n39a3

Palabras clave:

Proceso de descellularización, matriz extracelular, tejido, detergente, aplicaciones clínicas

Resumen

There is a persistent an urgent need to solve tissue and organ donor shortage issues. Decellularized tissues represent a promising alternative to other biologic and synthetic treatments that have been developed, since they aim to retain native tissue characteristics that would help in the regenerative processes such as prolifera-tion, cellular adhesion, and the presence of growth factors, while minimizing the chances of an unwanted host immune response. In the present review, we describe the most common methodologies for decellularization pro-cesses, as well as the clinical applications of these biomaterials.

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